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Bad sleep 'dramatically' alters body

By James Gallagher Health and science reporter, BBC News  

A run of poor sleep can have a potentially profound effect on the internal workings of the human body, say UK researchers.

The activity of hundreds of genes was altered when people's sleep was cut to less than six hours a day for a week.
Writing in the journal PNAS, the researchers said the results helped explain how poor sleep damaged health.
Heart disease, diabetes, obesity and poor brain function have all been linked to substandard sleep.
What missing hours in bed actually does to alter health, however, is unknown.
So researchers at the University of Surrey analysed the blood of 26 people after they had had plenty of sleep, up to 10 hours each night for a week, and compared the results with samples after a week of fewer than six hours a night.
More than 700 genes were altered by the shift. Each contains the instructions for building a protein, so those that became more active produced more proteins - changing the chemistry of the body.

Egypt suspends Luxor balloon flights after deadly crash

Governor of Luxor, Ezzat Saad: "I would like to offer my condolences"

The Egyptian authorities have suspended all hot air balloon flights near Luxor and launched an investigation following the deaths of 19 tourists in a crash.

Hong Kong, Japanese, British, French and Hungarian nationals were among those killed on Tuesday morning.
A landing rope is reported to have got caught around a helium gas tube and severed it, after which a fire erupted and the balloon shot up into the air.
It then plunged some 300m (1,000ft) to the ground in a field west of the city.
The pilot and one passenger survived by jumping out of the basket.

Adele's 21 tops 2012 global album chart

Adele's chart-topping album 21 has topped the global albums chart for a second consecutive year.

The album, released in January 2011, sold 8.3 million copies last year, the International Federation of the Phonographic Industry (IFPI) said.
Overall music revenues were up 0.3% to $16.5bn (£10.9bn) - the first year of industry growth since 1999.
Paul Williams, the head of business analysis at Music Week, said the rise was "very significant".
"After many, many years of decline the graph is finally heading northwards again," he said.
"It underlines the efforts the music industry has been putting in and the results it's now getting in reinventing itself in the digital era."
The IFPI's annual Digital Music Report also showed that digital revenues grew by 9% last year and now account for 34% of total revenue.
Carly Rae Jepsen's hit Call Me Maybe was the best-selling single of 2012, with 12.5 million units sold globally.

Adele outsold her nearest rival, Taylor Swift's Red, by some three million copies.

Former X Factor contestants One Direction had the third and fourth best-selling albums around the world with their first two records Up All Night and Take Me Home, with 4.5 million and 4.4 million copies sold respectively.
There were two other British acts in the top 10 - Rod Stewart's Merry Christmas, Baby was at number seven and Grammy winners Mumford and Sons' Babel was at nine.
Gotye's mega-hit Somebody That I Used To Know was the second biggest-selling single globally, with 11.8 million purchases.

Amour bags hat-trick of London Critics Circle Film Awards

 

 Amour also stars French film actor Jean-Louis Trintignant

 

Bafta and Oscar-nominated film Amour has bagged a hat-trick of London Critics' Circle Film Awards, including film and screenplay of the year for writer and director Michael Haneke.

French screen veteran Emmanuelle Riva was named actress of the year for her turn as an elderly music teacher who is struck down by a stroke.
Berberian Sound Studio was named British film of the year.
A single award for Les Miserables went to Anne Hathaway as supporting actress.
Amour won the Palme D'Or in Cannes in May last year, and picked up a Golden Globe award last week. It has been nominated for five Oscars and four Baftas.
Joaquin Phoenix and Phillip Seymour Hoffman, who both star in The Master, won best actor and best supporting actor respectively.
British actress of the year went to Bafta Rising star nominee Andrea Riseborough for her turn as an IRA informant in Shadow Dancer. Toby Jones was named best British actor for Berberian Sound Studio.
Jones told the BBC: "I'm genuinely surprised, it's an extraordinary category - and to be compared with such brilliant actors and for the film to be compared to such massive budget films."

Quadruple helix DNA seen in human cells

A representation of the four-stranded structure (L) with fluorescent markers revealing its presence inside cells (R) 

Cambridge University scientists say they have seen four-stranded DNA at work in human cells for the first time.

The famous "molecule of life", which carries our genetic code, is more familiar to us as a double helix.
But researchers tell the journal Nature Chemistry that the "quadruple helix" is also present in our cells, and in ways that might possibly relate to cancer.
They suggest that control of the structures could provide novel ways to fight the disease.
"The existence of these structures may be loaded when the cell has a certain genotype or a certain dysfunctional state," said Prof Shankar Balasubramanian from Cambridge's department of chemistry.
"We need to prove that; but if that is the case, targeting them with synthetic molecules could be an interesting way of selectively targeting those cells that have this dysfunction," he told BBC News.
Tag and track It will be exactly 60 years ago in February that James Watson and Francis Crick famously burst into the pub next to their Cambridge laboratory to announce the discovery of the "secret of life".
What they had actually done was describe the way in which two long chemical chains wound up around each other to encode the information cells need to build and maintain our bodies.
Today, the pair's modern counterparts in the university city continue to work on DNA's complexities.
Balasubramanian's group has been pursuing a four-stranded version of the molecule that scientists have produced in the test tube now for a number of years.
It is called the G-quadruplex. The "G" refers to guanine, one of the four chemical groups, or "bases", that hold DNA together and which encode our genetic information (the others being adenine, cytosine, and thymine).

UN report Torture in Afghan prisons is widespread

BBC's Quentin Somerville said the report details use of electric shock to extract confessions.

The United Nations says torture in Afghan prisons continues to be widespread despite its recommendations in a similar report in 2011.

More than half of the 635 detainees interviewed by UN investigators said they had been ill-treated or tortured.
The Afghan government says the claims are exaggerated, the BBC's Quentin Sommerville in Kabul says.
Nato's force in Afghanistan, Isaf, has suspended the transfer of detainees to facilities named in the report.
The report, by the United Nations Assistance Mission in Afghanistan (Unama), focused on detainees in facilities run by both national and local police forces and the intelligence services, the NDS, between October 2011 and October 2012.
Impunity charge It identified 14 methods of torture and ill-treatment practices, including beatings, a threat of execution and sexual abuse. Some were given electric shocks to extract confessions or obtain information.

Mali conflict French troops enter Diabaly

 

France says it will not leave until the whole of northern Mali is recaptured

A column of French and Malian troops has entered the key central Malian town of Diabaly, without resistance from militant Islamists, officials say.

About 30 armoured vehicles carrying some 200 French and Malian soldiers moved into the town, said an AFP reporter with the soldiers.
The Islamists fled the town on Friday after it was hit by French airstrikes.
France launched its military action in Mali more than a week ago to end the Islamist control of northern Mali.
France has sent some 2,000 troops to help Malian forces fight the militants, some of whom are linked to al-Qaeda in the Islamic Maghreb.
It has called on West African countries to speed up the deployment of a regional force of more than 3,000.

An Islamist group in Nigeria, says it carried out an attack last week which killed two Nigerian troops as they prepared to deploy to Mali.

Ansaru said it targeted the troops because the Nigerian military was joining efforts to "demolish the Islamic empire of Mali".

US shoots down Death Star superlaser petition

 
The White House response dashed the hopes of Star Wars fans

The White House has rejected a petition to build a Death Star - a huge battle-station armed with a superlaser as seen in the Star Wars films.

In a playful response, a senior US government official said the Obama administration "does not support blowing up planets".
The official also said the cost - about $850 quadrillion - was too high.
More than 34,000 people had signed the petition, saying the project would spur job creation and strengthen defence.
They also wanted the government to begin construction by 2016.
The White House is obliged to respond to all petitions that gain more than 25,000 signatures.
'Force be with us!'

China's landslide death toll rises to 46 - state media

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 A number of people remain missing after the landslide struck on Friday

At least 46 people, including children, are now known to have been killed by a landslide in China's southern Yunnan province, state media report.

The bodies of the last two missing residents of the Gaopo village, Yunnan province, were found in the morning, Xinhua news agency says.
The landslide hit the village at about 08:20 local time on Friday (23:00 GMT Thursday), burying 16 houses.